Horses evolved to thrive on wide open plains, where, as creatures of flight, their response reactions had to be very quick. This is reflected in their respiratory tract, which is designed for exerting maximum performance when fleeing predators. Since domestication, our expectations of our horses are quite the opposite, as they are often living and working in comparatively enclosed environments. This can create pressures for the modern horse, which is frequently evident in the health and integrity of the respiratory system. Management plays an important role in helping horses cope with these stresses, with targeted nutritional support offering invaluable help. Offering the right targeted, nutritional support can play a significant role in helping to meet the horse’s respiratory requirements.